Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer

Abstract

Although certain studies have demonstrated no association between the stromal cell-derived factor-1 (SDF1-3') G801A single nucleotide polymorphism (SNP) and cervical carcinoma, the interactions between the SDF1-3' G801A SNP and contraceptive use, menopausal status, parity and tobacco smoking remain to be fully elucidated. Using polymerase chain reaction-restriction fragment length polymorphism, the distribution of SDF1-3' G801A genotypes in patients with cervical cancer (n=462) against control groups (n=497) was investigated. Logistic regression analysis, adjusting for age, pregnancy, oral contraceptive use, tobacco smoking and menopausal status, did not identify the SDF1-3' G801A polymorphism as a genetic risk factor for cervical cancer. The adjusted odds ratio (OR) for patients with the A/G, vs. G/G genotype was 1.203, with a 95% confidence interval (CI) of 0.909-1.591 (P=0.196). The adjusted OR for the A/A, vs. G/G genotype was 1.296 (95% CI=0.930-1.807; P=0.125) and for the A/A or A/G, vs. G/G genotype was 1.262 (95% CI=0.964-1.653; P=0.090)]. The P-value of the χ2 test of the trend observed for the SDF1-3' G801A polymorphism was at the borderline of being statistically significant (ptrend=0.0484). Stratified analyses between the distribution of the SDF1-3' G801A genotypes and cervical cancer risks demonstrated that this polymorphism may be a risk factor for patients with a positive history of tobacco smoking (1.778; 95% CI=1.078-2.934; P=0.0235). These findings suggested that the SDF1-3' G801A polymorphism may be a genetic risk factor for cervical cancer in patients with a positive history of tobacco smoking.