The in vitro effects of Bordetella Pertussis lymphocytosis-promoting factor on murine lymphocytes: II. Nature of the responding cells*

Abstract

The mitogenic response of murine lymphocytes to the lymphocytosis-promoting factor of Bordetella pertussis has been shown to be due to activation of T cells. The selectivity of responsiveness to LPF with respect to the population ofT cells which is stimulated, differs from that of PHA as well as Con A, and the surface receptors are different. A population of adherent cells, which does not appear to consist of macrophages or other phagocytic cells, is required for the T-cell response. © American Society for Clinical Pathology.