Left Atrial Volume Index (LAVI) as an Indicator of Severity and Pulmonary Hypertension in Mitral Stenosis

Abstract

Left Atrial (LA) pressure and the trans-mitral pressure gradient chronically increases in Mitral Stenosis (MS), which results in LA enlargement and Pulmonary Hypertension (PH). We investigate the Left Atrial Volume Index (LAVI) as an indicator of severity and PH in MS. Fifty-nine subjects with MS (27 men and 32 women) mean ages 41.3±9.51 y.o were included in this study. We examined the correlation of LAVI and parameters of MS severity, and PH (Planimetry, MVA-PHT, MVA-VTI, MV-PHT, MV meanPG, TRmaxPG, and EstPASP). Most of the subjects had severe MS (77%), mild PH (40%) and AF (80%). LAVI value markedly increased in this study (Mean: 83.79 ± 38.32 ml/m2). In subjects with severe MS, LAVI was significantly higher than that in moderate MS (91.88±38.41 vs 54.83±19.28, p<0.05). LAVI was significantly correlated with Planimetry, MVA-PHT, MVA-VTI, MV-PHT, MV MeanPG, and EstPASP (-0.40;-0.42;-0.29; 0.42; 0.27 and 0.29, p<0.05, respectively). LAVI cut-off value as an indicator for severe MS was 59.72 ml/m2, with the sensitivity and specificity was 75.3% and 66%, respectively. LAVI was correlated well with severity and PH parameters in MS. LAVI also can be used as an indicator for severe MS.