Abstract
In this study, an improved process for the synthesis of etorphine and dihydroetorphine from codeine with an overall yield of 2.7% and 1.5% respectively is described. The structure of 19-propylthevinol 7 was verfied by X-ray structure analysis. This result is promising for synthesizing various morphine-based drugs.
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Huang, X. R., Srimurugan, S., Lee, G. H., & Chena, C. (2011). A facile synthesis and structural verification of etorphine and dihydroetorphine from codeine. Journal of the Chinese Chemical Society, 58(1), 101–107. https://doi.org/10.1002/jccs.201190048
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