The core human mitochondrial transcription initiation complex

  • Shutt T
  • Bestwick M
  • Shadel G
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Abstract

We recently demonstrated that the core transcription initiation complex in human mitochondria is two-component system (POLRMT and h-mtFB2). Human mtTFA/TFAM, previously proposed to be a requisite initiation complex member, is dispensable for promoter-specific initiation in vitro and we propose instead regulates relative promoter activity and/or overall nucleoid transcription and replication potential.

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Shutt, T. E., Bestwick, M., & Shadel, G. S. (2011). The core human mitochondrial transcription initiation complex. Transcription, 2(2), 55–59. https://doi.org/10.4161/trns.2.2.14296

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