RENOPROTECTIVE EFFECT of TAXIFOLIN AND/OR VITAMIN C on DIAZINON-INDUCED RENAL INJURY in RATS

Abstract

Insecticides have come to be used in a wrong way and uncontrollably, leading to an increase in the incidence of chronic diseases such as chronic nephropathies, diabetes, and other metabolic disorders. Objective: To evaluate the protective effect of Taxifolin and/or vitamin C against Diazinon-induced renal dysfunction. Methods: Thirty-six female rats were divided into six groups gavaged orally for 30 days. Group 1 received 20 mg/kg DZN. Group 2 received 25 mg/kg Taxifolin, 100 mg/kg vitamin C, and then 20 mg/kg DZN. Group 3 received 25 mg/kg Taxifolin and then 20 mg/kg DZN. Group 4 received 100 mg/kg vitamin C and then 20 mg/kg DZN. Group 5 received 25 mg/kg Taxifolin and then 100 mg/kg vitamin C. Finally, group 6 received distilled water. In the end, the rats were sacrificed and their blood and kidneys were collected for biochemical analysis and histopathology. Conclusion: Sub-acute administration of Taxifolin and vitamin C provides a renoprotective effect against oxidative stress induced by DZN.