mSphere of Influence: the Importance of Metabolism for Pathogen Adaptation to Host-Imposed Stresses

Abstract

Jorge Amich studies several aspects of sulfur and nitrogen metabolism in Aspergillus fumigatus , with the ultimate aim of identifying targets for the development of novel antifungals. In this mSphere of Influence article, he reflects on how “Sub-Telomere Directed Gene Expression during Initiation of Invasive Aspergillosis” (A. McDonagh, N. D. Fedorova, J. Crabtree, Y. Yu, S. Kim, et al., PLoS Pathog 4:e1000154, 2008, https://doi.org/10.1371/journal.ppat.1000154 ) impacted his thinking about in vivo metabolism and how to investigate it. Jorge Amich studies several aspects of sulfur and nitrogen metabolism in Aspergillus fumigatus , with the ultimate aim of identifying targets for the development of novel antifungals. In this mSphere of Influence article, he reflects on how “Sub-Telomere Directed Gene Expression during Initiation of Invasive Aspergillosis” (A. McDonagh, N. D. Fedorova, J. Crabtree, Y. Yu, S. Kim, et al., PLoS Pathog 4:e1000154, 2008, https://doi.org/10.1371/journal.ppat.1000154 ) impacted his thinking about in vivo metabolism and how to investigate it.