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SnapShot: Jak-STAT Signaling II

Cell
DOI: 10.1016/j.cell.2020.04.052
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Abstract

The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and transcription control. Discoveries in this field provided insights into primary immunodeficiencies, inherited autoimmune and autoinflammatory diseases, and hematologic and oncologic disorders, giving rise to a new class of drugs, JAK inhibitors (or Jakinibs).

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Villarino, A. V., Gadina, M., O’Shea, J. J., & Kanno, Y. (2020, June 25). SnapShot: Jak-STAT Signaling II. Cell. Cell Press. https://doi.org/10.1016/j.cell.2020.04.052

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