An upaate on the genome, epigenome, and transcriptome in gliomas

Abstract

The recent development of next-generation sequencing has enabled comprehensive genomic and epigenetic analyses in a variety of diseases, which has facilitated the understanding of the molecular biological mechanisms underpinning such diseases. The big data accumulated in this process has revealed the whole picture in glioma as well. Gliomas consist of various subtypes that are molecularly distinct from each other, and key molecules or aberrations have been identified. Such molecules are now being focused on as drug— targets. In this article, new technologies will be introduced and the future perspective is also discussed.