Unraveling the cellular heterogeneity of malignant pleural mesothelioma through a deconvolution approach

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Abstract

We determined the proportions of epithelioid-like and sarcomatoid-like cellular entities within malignant pleural mesothelioma samples, by deconvolution of their transcriptomes. These proportions are associated with prognosis and may guide therapeutic strategies. This novel approach describes both intra- and inter-tumor heterogeneity and provides a new way of thinking about cancer pathology.

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Blum, Y., Jaurand, M. C., De Reyniès, A., & Jean, D. (2019). Unraveling the cellular heterogeneity of malignant pleural mesothelioma through a deconvolution approach. Molecular and Cellular Oncology, 6(4). https://doi.org/10.1080/23723556.2019.1610322

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