Journal ArticleOPEN ACCESS

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis

Cell Host and Microbe (2019) 25(6) 845-857.e5
DOI: 10.1016/j.chom.2019.04.005
65Citations
Citations of this article
112Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Norovirus is an enteric virus that infects intestinal epithelial tuft cells in mice. Lee et al. discover that murine norovirus NS1 is an unconventionally secreted protein that overcomes IFN-λ-mediated norovirus control and is critical for intestinal infection in mice. Additionally, vaccination with NS1 alone confers protection, suggesting potential vaccine strategies.

Author supplied keywords

Cite

CITATION STYLE

APA

Lee, S., Liu, H., Wilen, C. B., Sychev, Z. E., Desai, C., Hykes, B. L., … Virgin, H. W. (2019). A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis. Cell Host and Microbe, 25(6), 845-857.e5. https://doi.org/10.1016/j.chom.2019.04.005

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free