C–H activation: A strategic approach toward lactams using transition metals

Abstract

The presence of lactam motif in surrounding biological and pharmaceutical arenas themselves calls for an easy and synthetically viable route toward its synthesis. There are multiple ways to achieve molecular targets; however, activating a C–H bond has attracted the chemical community for decades. Recent advances introduce a spectrum of mild routes to activate very inert C–H bonds, and here, it becomes highly important for the manufacturing of lactam moieties. Even the activation of distal-located C–H bonds can generate a chance of synthesizing macromolecules. In this review, we discuss the ways in which C–H activation can help to create molecular complexities containing lactam skeleton.