The synthesis of a bis(Thiosemicarbazone) macrocyclic ligand and the Mn(II), Co(II), Zn(II) and 68Ga(III) complexes

10Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

A 1,4,7,10-tetraazacyclododecane (cyclen) variant bearing two thiosemicarbazone pen-dant groups has been prepared. The ligand forms complexes with Mn2+, Co2+ and Zn2+. X-ray crystallography of the Mn2+, Co2+ and Zn2+ complexes showed that the ligand provides a six-coordinate environment for the metal ions. The Mn2+ and Zn2+ complexes exist in the solid state as racemic mixtures of the Δ(δ,δ,δ,δ)/Λ(λ,λ,λ,λ) and Δ(λ,λ,λ,λ)/Λ(δ,δ,δ,δ) diastereomers, and the Co2+ complex exists as the Δ(δ,δ,δ,δ)/Λ(λ,λ,λ,λ) and Δ(λ,λ,λ,δ)/Λ(δ,δ,δ,λ) diastereomers. Density functional theory calculations indicated that the relative energies of the diastereomers are within 10 kJ mol−1. Magnetic susceptibility of the complexes indicated that both the Mn2+ and Co2+ ions are high spin. The ligand was radiolabelled with gallium-68, in the interest of developing new positron emission tomography imaging agents, which produced a single species in high radiochemical purity (>95%) at 90 °C for 10 min.

Cite

CITATION STYLE

APA

Grieve, M. L., Davey, P. R. W. J., Forsyth, C. M., & Paterson, B. M. (2021). The synthesis of a bis(Thiosemicarbazone) macrocyclic ligand and the Mn(II), Co(II), Zn(II) and 68Ga(III) complexes. Molecules, 26(12). https://doi.org/10.3390/molecules26123646

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free