The therapeutic effect of deep brain stimulation at medial globus pallidus and subthalamic nucleus on treating parkinson disease

Abstract

Introduction: The objective was to explore the improvements and therapeutic effects of deep brain stimulation on the symptoms and living quality of patients with Parkinson disease. Materials and methods: A total of 82 patients with Parkinson disease who underwent deep brain stimulation in the Neurosurgery Department at The First Affiliated Hospital of Xi'an Jiaotong University from May 2016 to January 2019 were enrolled. The clinical symptoms, disease severity, disability, and quality of life of enrolled patients were evaluated at 1 week before the surgery and 6 months after the surgery. Results: 1. Given the "close" drug status, compared with the preoperative UPDRS (Unified Parkinson's Disease Rating Scale) scores, the sports examinations and activities of daily lives of patients decreased significantly (P<0.01). 2. Compared with the preoperative conditions, the Hoehn-Yahr staging and Schwab and England activities of daily lives were significantly improved during the "open" and "close" periods of the drug status (P<0.01). 3. The PDQ-39(Quality of life questionnaire for Parkinson-39) total scores of patients after the surgery decreased significantly compared with those before the surgery. Besides, the sports, activities of daily lives, and physical discomfort of patients were greatly improved after the surgery (P<0.01). Conclusion: Deep brain stimulation precisely.