In northern Western Australia in 2011 and 2012, surveillance detected a novel arbovirus in mosquitoes. Genetic and phenotypic analyses confirmed that the new flavivirus, named Fitzroy River virus, is related to Sepik virus and Wes-selsbron virus, in the yellow fever virus group. Most (81%) isolates came from Aedes normanensis mosquitoes, providing circumstantial evidence of the probable vector. In cell culture, Fitzroy River virus replicated in mosquito (C6/36), mammalian (Vero, PSEK, and BSR), and avian (DF-1) cells. It also infected intraperitoneally inoculated weanling mice and caused mild clinical disease in 3 intracranially inoculated mice. Specific neutralizing antibodies were detected in sentinel horses (12.6%), cattle (6.6%), and chickens (0.5%) in the Northern Territory of Australia and in a subset of humans (0.8%) from northern Western Australia.
CITATION STYLE
Johansen, C. A., Williams, S. H., Melville, L. F., Nicholson, J., Hall, R. A., Bielefeldt-Ohmann, H., … Smith, D. W. (2017). Characterization of fitzroy river virus and serologic evidence of human and animal infection. Emerging Infectious Diseases, 23(8), 1289–1299. https://doi.org/10.3201/eid2308.161440
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