TDP-43 is coming to the cottage: A new tool to study neurodegenerative diseases

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Abstract

In some neurodegenerative diseases, the protein TDP-43 is both lost from the nucleus and forms clumps in the cytoplasm. These two pathologies can be challenging to model, but a study in PLOS Biology presents a new system that captures both features.

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Rayner, S. L., & Gitler, A. D. (2026). TDP-43 is coming to the cottage: A new tool to study neurodegenerative diseases. PLOS Biology, 24(3), 1–4. https://doi.org/10.1371/journal.pbio.3003697

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