Studies on Pharmacologically Active Principles from Indonesian Crude Drugs: II: Hypothermic Principle from Curcuma xanthorrhiza ROXB

Abstract

Germacrone was identified as a hypothermic principle of Curcuma xanthorrhiza roxb. when orally administered to mice, germacrone showed the following activities in addition to the hypothermic effect: prolongation of pentobarbital-induced sleeping time, suppression of spontaneous motor activity, suppression of acetic acid-induced writhing, and inhibition of stress-induced ulcer. © 1988, The Pharmaceutical Society of Japan. All rights reserved.