Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution

Abstract

The anti-HIV nucleoside lamivudine was asymmetrically synthesized in only three steps via a novel surfactant-treated subtilisin Carlsberg-catalyzed dynamic kinetic resolution protocol. The enantiomer of lamivudine could also be accessed using the same protocol catalyzed by Candida antarctica lipase B. © 2013 The Royal Society of Chemistry.