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Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis

Nature Communications (2024) 15(1)
DOI: 10.1038/s41467-024-46665-2
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Abstract

Here the authors uncovered CNOT3, a subunit of the CCR4-NOT complex, as an essential modulator of translation in leukemia. The work pointed to the potential of targeting the posttranscriptional circuitry via CNOT3 as a therapeutic vulnerability in acute myeloid leukemia.

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Ghashghaei, M., Liu, Y., Ettles, J., Bombaci, G., Ramkumar, N., Liu, Z., … Vu, L. P. (2024). Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis. Nature Communications , 15(1). https://doi.org/10.1038/s41467-024-46665-2

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