Proton Radiotherapy Significantly Reduces Pneumonia in Patients With Esophageal Cancer

Abstract

Purpose: Neoadjuvant chemoradiation therapy (RT) (nCRT) followed by surgical resection is the current standard of care for patients with esophageal cancer (EC). This treatment is associated with a variety of complications, with pneumonia being the most common. We hypothesized that proton RT (PRT) can significantly reduce the incidence of pneumonia compared with photon RT (PhRT). Methods and Materials: We performed an analysis on a prospective cohort of patients with EC who completed nCRT with PRT or PhRT and underwent esophagectomy between October 2014 and June 2022. Multivariable logistic regression was used to analyze the effect of the RT technique on pneumonia while correcting for confounders. To access the dose-effect relationships, dose-volume histogram parameters of the lungs and the heart were analyzed using a principal component (PC) analysis. Results: We included 313 patients, of whom 28% developed pneumonia. The incidence was lower after PRT compared with PhRT (12% vs 32%, P