Use of 'Tremorine' for screening anti-parkinsonian drugs

Abstract

'TREMORINE' (1 : 4-dipyrrolidine-butyne) has been proposed1,2 as a test drug against which anti-Parkinsonian agents may be screened and evaluated by their effect on the tremor induced by 'Tremorine' in mice. We have investigated the action of the compound in toads, mice, rats and guinea pigs; trials with larger animals, dogs and cats, were restricted by the shortage of 'Tremorine'. © 1959 Nature Publishing Group.