Revealing Developmental Regionalization of Infant Cerebral Cortex Based on Multiple Cortical Properties

Abstract

The human brain develops dynamically and regionally heterogeneously during the first two postnatal years. Cortical developmental regionalization, i.e., the landscape of cortical heterogeneity in development, reflects the organization of underlying microstructures, which are closely related to the functional principles of the cortex. Therefore, prospecting early cortical developmental regionalization can provide neurobiologically meaningful units for precise region localization, which will advance our understanding on brain development in this critical period. However, due to the absence of dedicated computational tools and large-scale datasets, our knowledge on early cortical developmental regionalization still remains intact. To fill both the methodological and knowledge gaps, we propose to explore the cortical developmental regionalization using a novel method based on nonnegative matrix factorization (NMF), due to its ability in analyzing complex high-dimensional data by representing data using several bases in a data-driven way. Specifically, a novel multi-view NMF (MV-NMF) method is proposed, in which multiple distinct and complementary cortical properties (i.e., multiple views) are jointly considered to provide comprehensive observation of cortical regionalization process. To ensure the sparsity of the discovered regions, an orthogonal constraint defined in Stiefel manifold is imposed in our MV-NMF method. Meanwhile, a graph-induced constraint is also included to improve the compactness of the discovered regions. Capitalizing on an unprecedentedly large dataset with 1,560 longitudinal MRI scans from 887 infants, we delineate the first neurobiologically meaningful representation of early cortical regionalization, providing a valuable reference for brain development studies.