Characterizations of two bacterial persulfide dioxygenases of the metallo-β-lactamase superfamily

Abstract

Background: Persulfide dioxygenases (PDOs), which belong to the metallo-lactamase (MBL) enzyme superfamily, oxidize glutathione persulfide (GSSH). Results: Crystal structures and ITC data provide information on ligand binding by PDOs. Conclusion: MBLs share conserved amino acid residues, but the functions of these residues vary by class. Significance: These results provide criteria for distinguishing PDOs from other MBL superfamily members.