BTNL2 gene polymorphism and sarcoidosis susceptibility:A meta-analysis

Abstract

Background Butyrophilin-like 2 (BTNL2) rs2076530 gene polymorphism has been implicated in susceptibility to sarcoidosis. However, results from previous studies are not consistent. To assess the association of BTNL2 polymorphism and sarcoidosis susceptibility, a meta-analysis was performed. Methods PubMed, Embase were searched for eligible case-control studies. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Results Ten studies involving a total of 3303 cases and 2514 controls were included in this metaanalysis. Combined data indicated that BTNL2 rs2076530 polymorphism was associated with sarcoidosis susceptibility in allelic model (A vs. G, OR = 1.59, 95%CI: 1.47-1.72), dominant model (AA + AG vs. GG, OR = 2.10, 95%CI: 1.67- 2.65), and recessive model (AA vs. AG + GG, OR = 1.93, 95%CI: 1.49-2.50). Conclusions This meta-analysis indicates that BTNL2 rs2076530 polymorphism contributes to the risk of sarcoidosis.