Inclusion Complexation of β-Cyclodextrin with Some Sulfonamides in Aqueous Solution

Abstract

The interaction of β-cyclodextrin with some sulfonamides in aqueous solution has been investigated by circular dichroism, UV absorption, and solubility techniques. Solubility and spectral changes were quantitatively treated to obtain stoichiometric ratio, which was found to be 1: 1, formation constants, and thermodynamic parameters for inclusion complexation. All results suggest that steric and hydrophobic factors of the drugs were largely responsible for this interaction. © 1978, The Pharmaceutical Society of Japan. All rights reserved.