Facile and scalable disposable sensor based on laser engraved graphene for electrochemical detection of glucose

Abstract

A novel and highly sensitive disposable glucose sensor strip was developed using direct laser engraved graphene (DLEG) decorated with pulse deposited copper nanocubes (CuNCs). The high reproducibility (96.8%), stability (97.4%) and low cost demonstrated by this 3-step fabrication method indicates that it could be used for high volume manufacturing of disposable glucose strips. The fabrication method also allows for a high degree of flexibility, allowing for control of the electrode size, design, and functionalization method. Additionally, the excellent selectivity and sensitivity (4,532.2 μA/mM.cm 2), low detection limit (250 nM), and suitable linear range of 25 μM-4 mM, suggests that these sensors may be a great potential platform for glucose detection within the physiological range for tear, saliva, and/or sweat.