Recent advances in nitro-involved radical reactions

Abstract

Nitro-containing compounds are important structural moieties in drugs, natural products, and small molecule therapeutics, and are widely used in a variety of organic transformations. During the past decades, these compounds have received considerable attention from the synthetic chemistry community, since they have been successfully applied in the preparation of amines, oximes, alkenes, nitrones and alcohols through the radical-initiated pathway. Additionally, significant progress in the chemistry of nitro radicals has been witnessed, providing efficient and rapid access to nitro-containing compounds as well as isoxazoline derivatives. Recent advances in the radical reactions involving the nitro group and various transformations have been summarized in this review.