Discovery of HY•1: A Novel Multifunctional Skincare Ingredient With Antiaging and Skin Repair Properties

Abstract

Objectives: Skin aging, influenced by intrinsic and extrinsic factors, includes photoaging caused by UV radiation, leading to ROS production and skin damage. The objective of this work is to demonstrate HY-1, a three-peptide conjugate shown to have antioxidation, anti-inflammatory efficacy in vitro, and clinical benefits in anti-wrinkle, is an efficacious ingredient for skin aging. Method: The antioxidation efficacy was studied on the ROS test, and the antiaging efficacy was studied on ex vivo human skin. In the clinical study, 49 subjects aged between 26 and 54 with wrinkle concerns were recruited and instructed to apply the investigational cream containing HY-1 for 28 days. Wrinkle attributes were assessed by dermatologists. Instrumental measurements were also conducted. Results: In vitro studies of HY-1 on HSF and HaCaT cells demonstrated significant efficacy in scavenging reactive oxygen species (ROS) and exerting anti-inflammatory effects, as evidenced by decreased ROS production and reduced expression of interleukin-6 (IL-6). Clinical study demonstrated significant improvement in skin condition, including firmness, nourishment, and anti-wrinkle. Conclusion: HY-1 is a novel skincare ingredient, addressing the visible manifestations of aging and photodamage. Its multifaceted capabilities, encompassing antioxidant properties, enhancement of skin firmness, nourishment, and anti-wrinkle effects, represent a pioneering approach with the potential to provide a skincare alternative.