Antioxidant, anti-inflammatory and hepatoprotective effects of olive fruit pulp extract: in vivo and in vitro study

Abstract

The current study aimed to investigate the antioxidant, anti-inflammatory and hepatoprotective activity of olive fruit pulp extract (OFPE) through in vivo- and in vitro-based studies. Oral administration of OFPE demonstrated a significant reduction in liver biomarker enzymes, inflammatory marker (IL-6, TNF-α, and C-reactive protein (CRP)) level and recovered the antioxidant enzymes and total antioxidant capacity levels when compared to CCl4 treated group. The histopathological alterations were seen in CCl4 treated mice. The hepatocyte architecture was maintained in OFPE treated group as compared to the CCl4 treated group. The anti-inflammatory activity of the OFPE was evaluated through in vitro and was found to be similar with a reference drug, ibuprofen. Current findings revealed that OFPE displays hepatoprotective effect through enhancement of antioxidant enzyme level, reduction of anti-inflammatory and maintenance of hepatocyte architecture. Thus, olive fruit extract might be utilized as a therapeutic alternative in the treatment of hepatic complications.