Fast size-determination of intact bacterial plasmids using nanofluidic channels

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Abstract

We demonstrate how nanofluidic channels can be used as a tool to rapidly determine the number and sizes of plasmids in bacterial isolates. Each step can be automated at low cost, opening up opportunities for general use in microbiology labs.

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Frykholm, K., Nyberg, L. K., Lagerstedt, E., Noble, C., Fritzsche, J., Karami, N., … Westerlund, F. (2015). Fast size-determination of intact bacterial plasmids using nanofluidic channels. Lab on a Chip, 15(13), 2739–2743. https://doi.org/10.1039/c5lc00378d

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