ANTIARRHYTHMIC, HAEMODYNAMIC AND METABOLIC EFFECTS OF 3α‐AMINO‐5α‐ANDROSTAN‐2β‐OL‐17‐ONE HYDROCHLORIDE IN GREYHOUNDS FOLLOWING ACUTE CORONARY ARTERY LIGATION

Abstract

The antiarrhythmic, haemodynamic and metabolic effects of a new amino steroid, ORG6001, have been investigated in experimental acute myocardial infarction in anaesthetized greyhounds. ORG6001 administered either intravenously (1–10 mg/kg) or orally (50 mg/kg) significantly reduced the incidence of ventricular ectopic beats in the first 30 min after ligation of the left anterior descending coronary artery. In dogs pretreated with ORG6001, metabolic changes indicative of myocardial ischaemia (lactate production and potassium efflux) were less marked than those occurring in control animals. Antiarrhythmic doses of ORG6001 caused only minimal transient haemodynamic effects. These results suggest that ORG6001 may possess distinct advantages over presently‐used antiarrhythmic drugs in the prevention and treatment of the early arrhythmias which occur after myocardial infarction. 1975 British Pharmacological Society