Synthesis of cis- and trans-3-aminocyclohexanols by reduction of β-enaminoketones

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Abstract

We describe a protocol developed for the preparation of β-enaminoketones derived from 1,3-cyclohexanediones, and their subsequent reduction by sodium in THF-isopropyl alcohol to afford cis- and trans-3-aminocyclohexanols. © 2012 by the authors.

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Balbás, I. M., Mendoza, B. E. D., Fernández-Zertuche, M., Ordonez, M., & Linzaga-Elizalde, I. (2012). Synthesis of cis- and trans-3-aminocyclohexanols by reduction of β-enaminoketones. Molecules, 17(1), 151–162. https://doi.org/10.3390/molecules17010151

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