Hepatocellular adenoma associated with familial adenomatous polyposis coli

Abstract

Hepatocellular adenoma (HCA) is a benign liver tumor that most frequently occurs in youngwomen using oral contraceptives. We report a rare case of HCA in a 29 years old female with familial adenomatous polyposis (FAP). The first proband was her sister, who underwent a total colectomy and was genetically diagnosed as FAP. A tumor, 3.0 cm in diameter, was detected in theright lobe of the liver during a screening study for FAP. A colonoscopy and gastroendoscopy revealed numerous adenomatous polyps without carcinoma.The patient underwent a total colectomy and ileo-analanastomosis and hepatic posterior sectoriectomy. The pathological findings of the liver tumor were compatible with HCA. The resected specimen of the colon revealed multiplecolonic adenomatous polyps. Examination of genetic alteration revealed a germ-line mutation of theadenomatous polyposis coli (APC ) gene.Inactivation of the second APC allele was not found.Other genetic alterations in the hepatocyte nuclear factor1 alpha and β-catenin gene, which are reported to be associated with HCA, were not detected. Although FAP is reported to be complicated with various neoplasias in extracolic organs, only six cases of HCA associated with FAP, including the present case, have been reported. Additional reports will establish the precisemechanisms of HCA development in FAP patients. © 2012 Baishideng.