Antinociceptive, antipyretic and antimicrobial activities of chrozophora tinctoria extracts

Abstract

The antinociceptive, antipyretic and antimicrobial activities possessed by different solvent extracts of Chrozophora tinctoria were investigated. Analgesic activity of the crude methanol extract was studied using the hot plate and acetic acid-induced writhing methods and antipyretic activity using standard procedures on mice. Chrozophora tinctoria extract had highest latency time on the hot plate. The plant extracts reduced the number of abdominal constriction by 50 % at a dose of 150 mg/kg. The antipyretic effect of all doses tested was comparable to that of normal saline. Maximum decrease in the body temperature of the mice was observed at a dose of 300 mg/kg extract. Ethyl acetate extract revealed good antibacterial potential against Salmonella typhi (83 % inhibition) and Shigella sonnei (63 % inhibition). Chloroform extract showed highest antifungal activity against Rhizopus sp. (68 % inhibition).