Seizures after antiemetic treatment with high dose domperidone: Report of four cases

Abstract

The judicious use of antiemetic treatment has made chemotherapy tolerable for a considerable number of patients. As the dosage of antiemetic drugs is increased, however, so side effects particularly in the central nervous system are bound to increase in incidence and severity. We report the occurrence of seizures in four patients treated with high dose intravenous domperidone as prophylaxis against chemotherapy induced emesis. We conclude that caution should be exercised with the intravenous administration of high dose domperidone, particularly in patients receiving displatin.