Correlation between prolactin, thyroid, LH, FSH, estradiol and progesterone in the infertile women

Abstract

Background: An important global health issue, infertility affects a couple’s social, psychological, economic, and sexual well-being. A variety of issues stemming from abnormal hypothalamus pituitary ovarian axis dysfunction make up the hormonal diseases of the female reproductive system. The aim of the study was to find correlation between prolactin, thyroid, LH, FSH, estradiol and progesterone in the infertile women. Methods: Present study was hospital based descriptive, cross-sectional study. 150 infertile women were required in sample size. Serum LH, FSH, estradiol was measured on day 2 of menstrual cycle and also serum TSH and serum progesterone on day 21. Results: Around one third (38%) of the cases was married since more than 10 years. Majority 108 (72%) had primary infertility and 50% of the women had history of irregular menstrual cycles. There was significant positive correlation between TSH and prolactin (p value <0.05) and significant negative correlation of TSH with FSH and LH (p value <0.05) and there was insignificant negative correlation of TSH with estrogen (D2) and progesterone (D21). The mean value of TSH in our study was 7.47±1.82 μIU/ml. Conclusions: TSH has strong positive co-relation between prolactin, FSH and LH indicating role in female infertility. These hormonal evaluations allow a routine etiological approach to the diagnosis of infertility.