Exploration of the connection between severe perioperative complications and preoperative basic diseases of surgical patients with non-small cell lung cancer

Abstract

Objective To explore the connection between severe perioperative complications and preoperative basic diseases of surgical patients with non-small cell lung cancer (NSCLC). Methods We retrospectively analyzed the data of surgical patients with NSCLC from January 1, 2016 to December 31, 2018 in Cancer Hospital, Chinese Academy of Medical Sciences (CAMS). The single factor analysis and logistic multivariate regression analysis were conducted to explicate the correlation of the risk factors especially preoperative basic diseases with severe perioperative complications. Results A total of 12,650 cases meeting our inclusion and exclusion criteria were included, of whom 5,409 (42.76%) cases had various preoperative basic diseases and 140 (1. 11%) cases occurred severe perioperative complications. Pulmonary and intrathoracic complications and circulatory system complications dominantly accounted for the severe perioperative complications, with incidence of 0.64% and 0.25%, respectively. The gender, age, tumor differentiation, surgical method, surgical approach, and preoperative basic diseases were significantly associated with the occurrence of severe perioperative complications in surgical patients with NSCLC according to the single factor analysis outcomes (P<0.05). Patients with pulmonary disease (P = 0.02), heart disease (P =0.03) and diabetes (P = 0.02) were more likely to occur severe complications according to the multivariate analysis outcomes. Conclusions The forms of severe perioperative complications of surgical patients with NSCLC are various. Patients with pulmonary disease, heart disease and diabetes are likely to occur severe complications, besides patients with male sex, elder age, poorly differentiated tumor, and undergoing open thoracotomy. We should take more effective measures to avoid severe complications when deal with these patients.