Long lasting effect of oral molsydomine on exercise performance. A new antianginal agent

Abstract

This study examines whether the beneficial effects of molsydomine, a recently antianginal agent, on exercise performance of patients with angina pectoris are long lasting. The hemodynamic effects are known to persist for several hours. The effects of molsydomine on the duration of exercise and the time to the onset of ST depression were compared to those of placebo during 2 hr after oral administration. Molsydomine prolonged the duration of exercise in all 8 patients (average .8 min, P <0.001) and delayed the onset of ST depression (average 2.2 min, P <0.001), while the placebo failed to alter these measurements. The increment of the duration of exercise produced by 2 mg of molsydomine in 2 hr following oral administration was comparable to the increment produced in a few minutes after 0.3 mg of nitroglycerin given sublingually. The results indicate that molsydomine offers prophylaxis for angina pectoris that lasts at least 2 hr after oral administration.