A general method for acylation of 1,3-dialkyl-substituted barbituric and 2-thiobarbituric acids

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Abstract

A sodium derivative of 1,3-dimethylbarbituric acid or 1,3-diethyl-2-thiobarbituric acid undergoes an efficient acylation reaction at the position 5 by treatment with an acyl chloride in the presence of pyridine.

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Strekowski, L., Ismail, M. A., & Zoorob, H. H. (1999). A general method for acylation of 1,3-dialkyl-substituted barbituric and 2-thiobarbituric acids. Heterocyclic Communications, 5(1), 9–10. https://doi.org/10.1515/HC.1999.5.1.9

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