Octanorcucurbitane triterpenoids protect against tert-butyl hydroperoxide-induced hepatotoxicity from the stems of Momordica charantia

Abstract

Four novel octanorcucurbitane triterpenes, octanorcucurbitacins A-D (1-4), together with one known octanorcucurbitane triterpene, kuguacin M (5), were isolated from the methyl alcohol extract of the stems of Momordica charantia. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compound 3 inhibited tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity against HepG2 cells. © 2010 Pharmaceutical Society of Japan.