Design and synthesis of self-assembling peptides

Abstract

Bis-acyl [CO-(CH2)n-CO; n = 0, 1, 2.....8] units have been identified as suitable molecular inserts which when placed at the core of symmetric retro or normal peptides show a strong tendency to generate highly regular and extensively hydrogen-bonded supramolecular assemblies of relevance in protein design and in developing novel peptide based materials.