Electrochemical Behavior and Voltammetric Determination of Albendazole Using Carbon Paste Electrode

Abstract

Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques were used to study the electrochemical activity of albendazole (ABZ) in carbon paste electrodes (CPE). Using Britton-Robinson (BR) buffer (pH 4.01) ABZ, only one oxidation peak (Ep = 0.873 V) was observed, suggesting that the irreversible oxidation mechanism and this process are regulated by adsorption. The various experimental parameters for oxidation of ABZ have been customized. The oxidation peak current is proportional to the concentrations of ABZ within the range from 0.0265 to 0.1855 gg/ml under optimum conditions. The limits of detection and quantification obtained are 0.015 and 0.048 gg/mL. This approach was used in drug products and human urine samples for the voltammetric detection of ABZ.