Synthesis, characterization, and biological studies of in vitro antibacterial, and cytotoxic activities of norfloxacin based square pyramidal copper(Ii) complexes

Abstract

The substantial increase in copper-containing complexes' research to treat bacterial infections encouraged us to synthesize fluoroquinolone drug norfloxacin (NFLH) based copper complexes. In this work, we presented the synthesis of mixed ligand Cu complexes with the basic structural formula [Cu(NFL)(A1)Cl], where An is isatin-based ligands. The characterization of compounds by Mass, FT-IR, UV-Vis spectroscopy, magnetic measurement, and conductivity measurement revealed the neutral nature and square pyramidal geometry of all the copper compounds. The biological screening of compounds displayed the potent bacteriostatic activity of copper compounds compare with the standard drug against four medically significant pathogens. The in vitro cytotoxic activity of copper compounds was checked on artemia cyst. The biological studies data are promising for their application as medicinally important compounds for future perspective.