Latest Developments in Metalloenzyme Design and Repurposing

Abstract

In the past decade, artificial metalloenzymes (AMEs) have emerged as attractive alternatives to more traditional homogeneous catalysts and enzymes. This microreview presents a selection of recent achievements in the design of such hybrid catalysts. These include artificial zinc hydrolases and metathesases, the heme-protein repurposing for C-H, N-H, and S-H insertion reactions, novel light-driven redox hybrid catalysts, novel scaffold proteins, and metallocofactor anchoring techniques and metalloenzyme models. Artificial metalloenzymes (AMEs) combine homogeneous catalysis with enzymatic catalysis. In this microreview the authors describe recent developments in this fascinating field, ranging from artificial zinc hydrolases, metathesases, new heme protein reactions to light-driven redox reactions and enzyme models.