N-(hydroxymethyl)ibogaine

Abstract

The title compound (systematic name: 16-hydroxy-methyl-12-methoxy- ibogamine), C21H28N2O2, was prepared by reaction of ibogaine with a formaldehyde-acetic acid solution (pH = 4). The crystal structure of this new product, belonging to the iboga indole family, is stabilized by an inter-molecular O - H⋯N hydrogen bond. The identity of the compound was confirmed by one- and two-dimensional NMR spectroscopic techniques.