In vitro cytotoxicity of hydrazones, pyrazoles, pyrazolo-pyrimidines, and pyrazolo-pyridine synthesized from 6-substituted 3-formylchromones

Abstract

Pyrazoles 4a-f, hydrazones 5a-c and 6a-c, pyrazolo[1,5-a]pyrimidines 7a, b, and pyrazolo[3,4-b]pyridine 8 were prepared in good yields (80-95%) from the reaction of 6-substituted (H, Me, F) 3-formylchromones 1a-c with N-substituted hydrazines 2a-c and aminopyrazole 3. The cytotoxicity of the synthesized compounds was assessed through the brine shrimp lethality assay. IC50 values were between 80 and 300 μm. Fluorine substitution decreased IC50 values.