Strategies for mapping susceptibility genes in age-related maculopathy

Abstract

The prospects for mapping genes conferring susceptibility to common disorders such as age-related maculopathy have increased as a result of advances in high-throughput genotyping using single nucleotide polymorphisms. This should not obscure the magnitude of the task of identifying what are potentially a diverse group of genetic variants with small or intermediate effects on disease susceptibility. Strategies for increasing the odds of success in such an endeavour are discussed.