Predictive factors of antidepressant response and remission to bupropion extended-release or psychosexual therapy among infertile women with sexual dysfunction

Abstract

Objectives: This study aimed to evaluate the predictive factors of antidepressant response and remission to bupropion extended-release (BUP ER) or psychosexual therapy (PST) among infertile women with sexual dysfunction (SD). Materials and Methods: As a randomized controlled clinical trial, this prospective study was carried out on 3 groups of BUP ER (n = 31), PST (n = 31), and control (n = 31) in infertile women with SD in Babol, Iran during 2014-2015. Logistic regression was used to detect predictors of antidepressant response and remission. Results: Antidepressant response and remission rates were 58.1% and 54.8 % respectively in the PST group. Of the infertile women in the BUP group, 41.9% reached response and remission by the end of the study. The results for PST contained 2 predictors: occupation in response and remission (odds ratio [OR] = 0.171, P = 0.036; OR = 0.1, P = 0.013; respectively), and frequency of sexual intercourse in response (OR = 0.124; P = 0.040). The results for BUP contained three predictors: baseline severe depression level in remission (OR = 0.044, P = 0.010), economic status in response and remission (OR = 5.850, P = 0.027), and age difference of spouses in response (P = 0.031). Conclusions: Depression screening and physician notification of demographic, reproductive and clinical predictors of antidepressant response and remission are necessary for selecting effective treatment interventions.