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Molecular design of hairpin imidazole-pyrrole polyamide for effective DNA alkylation.

Nucleic acids research. Supplement (2001) (2001) (1) 225-226
DOI: 10.1093/nass/1.1.225
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Abstract

A new type of hairpin polyamide-CPI conjugate possessing a vinyl linker has been synthesized. Sequence-selective alkylation of double-stranded DNA by conjugates was investigated by high resolution denaturing gel electrophoresis using 450 bp DNA fragments. Highly-efficient DNA alkylation predominantly occurs at the purines of 5'-(A/T)G(T/A)CPu-3' site at nanomolar concentration.

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APA

Bando, T., Narita, A., Saito, I., & Sugiyama, H. (2001). Molecular design of hairpin imidazole-pyrrole polyamide for effective DNA alkylation. Nucleic Acids Research. Supplement (2001), (1), 225–226. https://doi.org/10.1093/nass/1.1.225

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