AB0147 RESEARCH PROGRESS OF MESENCHYMAL STEM CELL-DERIVEDMICROVESICLES BY DELIVERING MICRORNA IN RHEUMATIC DISEASES

Abstract

Background: Recently, studies have shown that Mesenchymal Stem Cellderived Microvesicles(MSC-MVs) can play a role in immune regulation and tissue repair by transporting miRNAs, and their effects are not weaker than that of their mother stem cells. Rheumatoid arthritis is an autoimmune disease characterized by chronic synovitis and progressive cartilage and bone destruction. Current treatments include non-steroidal anti-inflammatory drugs, glucocorticoids, DMARDs, and biological agents, but 30% of patients with rheumatism are ineffective, so there is an urgent need to find a new treatment. Objectives: To review the research progress of MSC-MVs by delivering micro-RNA(miRNA) in rheumatic diseases. Methods: Literatures were searched by using MSC-MVs, autoimmune diseases and miRNAas keywords. Results: In the field of rheumatology, Chen C showed that after MSCT transplantation, mir-151-5p was transferred through exosomes to damaged bone marrow MSC of systemic sclerosis(SSc) mice, and the activation of IL4R/mTOR pathway was down-regulated to improve the osteoporosis of SSc mice [1].Exosomes of human synovial mesenchymal stem cells overexpressing miR-140-5p promoted cartilage regeneration and prevented OA in rat models [2].In the field of autoimmune deseases, Chen L et al. demonstrated that BMSC-derived exosomes containing miR-223 play a important role in liver protection by down-regulating NLRP3 (nod-like receptor family protein) and caspase-1 (caspase-1) in the experimental model of autoimmune hepatitis[3].Human BMSC-derived exosomes transfected with siFas and anti-mir-375 plasmids down-regulated Fas and miR-375 in human NOD scid gamma (NSG) mice, thereby protecting islet function and inhibiting immune rejection in islet transplantation [4]. Conclusion: MiRNA targeting therapy with MSC-MVs as vector or the construction of MSC-MVs with overexpression of protective miRNA will provide new, accurate and promising treatment strategies for multiple rheumatic diseases.